Drug interactions
Roflumilast + Stiripentol
Severity: Minor
Roflumilast and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has both inhibitory and inducing effects on CYP enzymes including CYP3A4 and CYP1A2, so roflumilast exposure could change in either direction. The net effect is unpredictable.
What this interaction means in plain words
Roflumilast and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Roflumilast belongs to Respiratory; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol variably inhibits and induces CYP3A4 and CYP1A2, altering roflumilast metabolism.
What to do
Monitor COPD control and roflumilast adverse effects after starting or stopping stiripentol. Adjust therapy based on response and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Roflumilast
Other interactions of Stiripentol
Frequently asked questions
Can I take Roflumilast with Stiripentol?
MediHelp rates the interaction as minor. Roflumilast and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol has both inhibitory and inducing effects on CYP enzymes including CYP3A4 and CYP1A2, so roflumilast exposure could change in either direction. The net effect is unpredictable.
How serious is the interaction between Roflumilast and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor COPD control and roflumilast adverse effects after starting or stopping stiripentol. Adjust therapy based on response and tolerability.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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