Drug interactions
Rolapitant + Venlafaxine
Severity: Moderate
Rolapitant and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine is converted by CYP2D6 to desvenlafaxine, and rolapitant inhibits this enzyme for weeks. Parent venlafaxine exposure may rise, increasing blood pressure, nausea, and serotonergic effects.
What this interaction means in plain words
Rolapitant and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rolapitant belongs to Gastrointestinal Tract; Venlafaxine belongs to Central Nervous System.
Why it happens
Rolapitant inhibits CYP2D6-mediated metabolism of venlafaxine.
What to do
Monitor blood pressure and for serotonergic or adverse effects. Lower the venlafaxine dose if poorly tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Rolapitant with Venlafaxine?
MediHelp rates the interaction as moderate. Rolapitant and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine is converted by CYP2D6 to desvenlafaxine, and rolapitant inhibits this enzyme for weeks. Parent venlafaxine exposure may rise, increasing blood pressure, nausea, and serotonergic effects.
How serious is the interaction between Rolapitant and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for serotonergic or adverse effects. Lower the venlafaxine dose if poorly tolerated.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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