Drug interactions
Rosiglitazone + Rosuvastatin
Severity: Minor
Rosiglitazone and Rosuvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rosiglitazone shows weak OATP1B1 inhibition in vitro, but no meaningful change in rosuvastatin exposure has been demonstrated clinically.
What this interaction means in plain words
Rosiglitazone and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rosiglitazone belongs to Endocrine; Rosuvastatin belongs to Cardiovascular.
Why it happens
Theoretical weak OATP1B1 inhibition; clinical relevance is not established.
What to do
No dose adjustment is needed. Review any muscle symptoms as for any statin user.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosuvastatin
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Rosiglitazone with Rosuvastatin?
MediHelp rates the interaction as minor. Rosiglitazone and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rosiglitazone shows weak OATP1B1 inhibition in vitro, but no meaningful change in rosuvastatin exposure has been demonstrated clinically.
How serious is the interaction between Rosiglitazone and Rosuvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Review any muscle symptoms as for any statin user.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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