Drug interactions
Rosiglitazone + Tecovirimat
Severity: Minor
Rosiglitazone and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat weakly inhibits CYP2C8 and CYP2C19, which metabolize rosiglitazone, so rosiglitazone exposure may rise modestly. This could increase glucose-lowering effect and fluid retention.
What this interaction means in plain words
Rosiglitazone and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rosiglitazone belongs to Endocrine; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak inhibition of CYP2C8 (the main pathway for rosiglitazone) and CYP2C19 reduces rosiglitazone clearance.
What to do
Monitor blood glucose and for hypoglycemia or edema during the short tecovirimat course. Adjust the rosiglitazone dose only if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Rosiglitazone with Tecovirimat?
MediHelp rates the interaction as minor. Rosiglitazone and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat weakly inhibits CYP2C8 and CYP2C19, which metabolize rosiglitazone, so rosiglitazone exposure may rise modestly. This could increase glucose-lowering effect and fluid retention.
How serious is the interaction between Rosiglitazone and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and for hypoglycemia or edema during the short tecovirimat course. Adjust the rosiglitazone dose only if needed.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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