Drug interactions
Rosiglitazone + Testosterone
Severity: Minor
Rosiglitazone and Testosterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Testosterone may improve insulin sensitivity and lower glucose in some patients, potentially adding to the effect of rosiglitazone. The effect is usually modest, but glucose lowering may be noticeable in people with hypogonadism.
What this interaction means in plain words
Rosiglitazone and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rosiglitazone belongs to Endocrine; Testosterone belongs to Endocrine.
Why it happens
Possible additive improvement in insulin sensitivity; the mechanism is not firmly established.
What to do
Monitor blood glucose after starting or changing testosterone therapy. Reduce the antidiabetic dose if glucose runs low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
Frequently asked questions
Can I take Rosiglitazone with Testosterone?
MediHelp rates the interaction as minor. Rosiglitazone and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Testosterone may improve insulin sensitivity and lower glucose in some patients, potentially adding to the effect of rosiglitazone. The effect is usually modest, but glucose lowering may be noticeable in people with hypogonadism.
How serious is the interaction between Rosiglitazone and Testosterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing testosterone therapy. Reduce the antidiabetic dose if glucose runs low.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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