Drug interactions
Rosiglitazone + Tipranavir
Severity: Moderate
Rosiglitazone and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors, including ritonavir-boosted tipranavir, can cause insulin resistance and hyperglycemia, which may reduce the efficacy of rosiglitazone. Ritonavir-boosted tipranavir also has complex enzyme-modulating effects that may alter rosiglitazone exposure.
What this interaction means in plain words
Rosiglitazone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosiglitazone belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Protease inhibitor-related insulin resistance antagonizes rosiglitazone, and there may also be metabolic enzyme modulation.
What to do
Monitor blood glucose and HbA1c when starting or stopping tipranavir. Adjust the antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Rosiglitazone with Tipranavir?
MediHelp rates the interaction as moderate. Rosiglitazone and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors, including ritonavir-boosted tipranavir, can cause insulin resistance and hyperglycemia, which may reduce the efficacy of rosiglitazone. Ritonavir-boosted tipranavir also has complex enzyme-modulating effects that may alter rosiglitazone exposure.
How serious is the interaction between Rosiglitazone and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or stopping tipranavir. Adjust the antidiabetic therapy as needed.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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