Drug interactions
Rosuvastatin + Roxadustat
Severity: Moderate
Rosuvastatin and Roxadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Roxadustat increases rosuvastatin exposure, which raises the risk of dose-related statin adverse effects such as myopathy. Patients with renal impairment are particularly susceptible.
What this interaction means in plain words
Rosuvastatin and Roxadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosuvastatin belongs to Cardiovascular; Roxadustat belongs to Miscellaneous.
Why it happens
Roxadustat inhibits OATP1B1 and BCRP transporters that handle rosuvastatin.
What to do
Monitor for muscle symptoms and consider lowering the rosuvastatin dose. Check CK if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roxadustat
- Gemfibrozil + Roxadustat Major
- Probenecid + Roxadustat Major
- Atorvastatin + Roxadustat Moderate
- Calcium acetate + Roxadustat Moderate
- Calcium + Roxadustat Moderate
- Iron + Roxadustat Moderate
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Rosuvastatin with Roxadustat?
MediHelp rates the interaction as moderate. Rosuvastatin and Roxadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Roxadustat increases rosuvastatin exposure, which raises the risk of dose-related statin adverse effects such as myopathy. Patients with renal impairment are particularly susceptible.
How serious is the interaction between Rosuvastatin and Roxadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and consider lowering the rosuvastatin dose. Check CK if symptoms develop.
What other medicines interact with Roxadustat?
MediHelp also lists interactions of Roxadustat with, for example, Gemfibrozil, Probenecid, Atorvastatin. The full list is on the Roxadustat page.
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