Drug interactions
Rosuvastatin + Trofinetide
Severity: Moderate
Rosuvastatin and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide inhibits hepatic OATP transporters in vitro and may raise rosuvastatin exposure. This could raise the risk of muscle toxicity.
What this interaction means in plain words
Rosuvastatin and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rosuvastatin belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Inhibition of OATP1B1/1B3 reduces hepatic uptake of rosuvastatin.
What to do
Monitor for muscle pain and weakness. Consider a lower rosuvastatin dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Trofinetide
Frequently asked questions
Can I take Rosuvastatin with Trofinetide?
MediHelp rates the interaction as moderate. Rosuvastatin and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide inhibits hepatic OATP transporters in vitro and may raise rosuvastatin exposure. This could raise the risk of muscle toxicity.
How serious is the interaction between Rosuvastatin and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain and weakness. Consider a lower rosuvastatin dose if symptoms occur.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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