Drug interactions
Rucaparib + Sertraline
Severity: Minor
Rucaparib and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C19 in vitro and may raise sertraline exposure, since CYP2C19 contributes to sertraline metabolism. Higher sertraline levels could increase serotonergic and gastrointestinal adverse effects.
What this interaction means in plain words
Rucaparib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Rucaparib inhibition of CYP2C19-mediated sertraline metabolism.
What to do
Monitor for sertraline adverse effects such as nausea, tremor and agitation. Reduce the sertraline dose if these appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Sertraline?
MediHelp rates the interaction as minor. Rucaparib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP2C19 in vitro and may raise sertraline exposure, since CYP2C19 contributes to sertraline metabolism. Higher sertraline levels could increase serotonergic and gastrointestinal adverse effects.
How serious is the interaction between Rucaparib and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sertraline adverse effects such as nausea, tremor and agitation. Reduce the sertraline dose if these appear.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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