Drug interactions
Rucaparib + Terbinafine
Severity: Minor
Rucaparib and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits several CYP enzymes, so terbinafine exposure could rise modestly. Terbinafine has multiple clearance pathways, so the effect is likely small.
What this interaction means in plain words
Rucaparib and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Terbinafine belongs to Anti Fungals.
Why it happens
Rucaparib weakly to moderately inhibits CYP1A2, CYP2C9 and CYP3A4, which contribute to terbinafine metabolism.
What to do
No dose change is expected to be needed; monitor for terbinafine adverse effects such as gastrointestinal upset or liver enzyme elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Terbinafine?
MediHelp rates the interaction as minor. Rucaparib and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits several CYP enzymes, so terbinafine exposure could rise modestly. Terbinafine has multiple clearance pathways, so the effect is likely small.
How serious is the interaction between Rucaparib and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is expected to be needed; monitor for terbinafine adverse effects such as gastrointestinal upset or liver enzyme elevation.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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