Drug interactions
Rucaparib + Ticagrelor
Severity: Moderate
Rucaparib and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A4 inhibitor in vitro and may increase ticagrelor exposure. Higher exposure could raise the risk of bleeding. Rucaparib can also cause thrombocytopenia, adding to bleeding risk.
What this interaction means in plain words
Rucaparib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rucaparib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Rucaparib inhibits CYP3A4, reducing ticagrelor metabolism.
What to do
Monitor for bleeding and platelet counts during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Ticagrelor?
MediHelp rates the interaction as moderate. Rucaparib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a moderate CYP3A4 inhibitor in vitro and may increase ticagrelor exposure. Higher exposure could raise the risk of bleeding. Rucaparib can also cause thrombocytopenia, adding to bleeding risk.
How serious is the interaction between Rucaparib and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and platelet counts during co-therapy.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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