Drug interactions
Rucaparib + Tinidazole
Severity: Minor
Rucaparib and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and other CYP enzymes, and tinidazole is only partly metabolized by CYP3A4. A clinically relevant rise in tinidazole levels is unlikely.
What this interaction means in plain words
Rucaparib and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Tinidazole belongs to Anti Parasitic.
Why it happens
Weak inhibition of CYP3A4-mediated tinidazole metabolism by rucaparib.
What to do
No dose adjustment is needed; monitor for tinidazole adverse effects such as nausea and metallic taste.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Tinidazole?
MediHelp rates the interaction as minor. Rucaparib and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and other CYP enzymes, and tinidazole is only partly metabolized by CYP3A4. A clinically relevant rise in tinidazole levels is unlikely.
How serious is the interaction between Rucaparib and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for tinidazole adverse effects such as nausea and metallic taste.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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