Drug interactions
Rucaparib + Tolbutamide
Severity: Moderate
Rucaparib and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C9 and can raise exposure to sensitive substrates such as tolbutamide. This may increase and prolong the glucose-lowering effect, with a risk of hypoglycemia.
What this interaction means in plain words
Rucaparib and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rucaparib belongs to Oncology; Tolbutamide belongs to Endocrine.
Why it happens
Rucaparib inhibits CYP2C9, reducing tolbutamide metabolism.
What to do
Monitor blood glucose during co-administration and reduce the tolbutamide dose if needed. Consider an alternative antidiabetic agent that does not rely on CYP2C9.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Tolbutamide?
MediHelp rates the interaction as moderate. Rucaparib and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib inhibits CYP2C9 and can raise exposure to sensitive substrates such as tolbutamide. This may increase and prolong the glucose-lowering effect, with a risk of hypoglycemia.
How serious is the interaction between Rucaparib and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during co-administration and reduce the tolbutamide dose if needed. Consider an alternative antidiabetic agent that does not rely on CYP2C9.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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