Drug interactions
Rucaparib + Umeclidinium-vilanterol
Severity: Minor
Rucaparib and Umeclidinium-vilanterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 to a modest degree and might slightly increase vilanterol exposure. A clinically meaningful change is unlikely at inhaled doses.
What this interaction means in plain words
Rucaparib and Umeclidinium-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Rucaparib inhibits CYP3A4, slightly reducing vilanterol metabolism.
What to do
No routine dose change is needed; monitor for tachycardia and tremor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Umeclidinium-vilanterol?
MediHelp rates the interaction as minor. Rucaparib and Umeclidinium-vilanterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP3A4 to a modest degree and might slightly increase vilanterol exposure. A clinically meaningful change is unlikely at inhaled doses.
How serious is the interaction between Rucaparib and Umeclidinium-vilanterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for tachycardia and tremor.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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