Drug interactions
Rucaparib + Vinblastine
Severity: Moderate
Rucaparib and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate inhibitor of CYP3A4 in vitro and may increase vinblastine exposure. Higher exposure could worsen myelosuppression, which rucaparib itself also causes.
What this interaction means in plain words
Rucaparib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rucaparib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
CYP3A4 inhibition by rucaparib reduces vinblastine metabolism, with additive myelosuppression.
What to do
Monitor complete blood counts and neurologic toxicity. Reduce vinblastine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rucaparib and Vinblastine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vinblastine
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Vinblastine?
MediHelp rates the interaction as moderate. Rucaparib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a moderate inhibitor of CYP3A4 in vitro and may increase vinblastine exposure. Higher exposure could worsen myelosuppression, which rucaparib itself also causes.
How serious is the interaction between Rucaparib and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and neurologic toxicity. Reduce vinblastine dose if toxicity develops.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
