Drug interactions
Rucaparib + Warfarin
Severity: Moderate
Rucaparib and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C9, CYP1A2 and CYP3A, the enzymes that clear warfarin enantiomers. Exposure to warfarin may therefore rise, increasing INR and bleeding risk.
What this interaction means in plain words
Rucaparib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rucaparib belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C9, CYP1A2 and CYP3A by rucaparib reduces warfarin clearance.
What to do
Monitor INR more often when rucaparib is started or stopped. Reduce the warfarin dose if INR rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Warfarin?
MediHelp rates the interaction as moderate. Rucaparib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib inhibits CYP2C9, CYP1A2 and CYP3A, the enzymes that clear warfarin enantiomers. Exposure to warfarin may therefore rise, increasing INR and bleeding risk.
How serious is the interaction between Rucaparib and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more often when rucaparib is started or stopped. Reduce the warfarin dose if INR rises.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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