Drug interactions
Rucaparib + Zafirlukast
Severity: Minor
Rucaparib and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C9 and may increase zafirlukast concentrations. The clinical effect is likely small but could increase zafirlukast adverse effects.
What this interaction means in plain words
Rucaparib and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rucaparib belongs to Oncology; Zafirlukast belongs to Respiratory.
Why it happens
Rucaparib inhibits CYP2C9, reducing zafirlukast metabolism.
What to do
Monitor for zafirlukast adverse effects such as headache or gastrointestinal upset. Reduce the zafirlukast dose if clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rucaparib with Zafirlukast?
MediHelp rates the interaction as minor. Rucaparib and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP2C9 and may increase zafirlukast concentrations. The clinical effect is likely small but could increase zafirlukast adverse effects.
How serious is the interaction between Rucaparib and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for zafirlukast adverse effects such as headache or gastrointestinal upset. Reduce the zafirlukast dose if clinically indicated.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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