Drug interactions
Ruxolitinib + Secobarbital
Severity: Moderate
Ruxolitinib and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ruxolitinib is cleared mainly by CYP3A4, and strong inducers can lower its exposure, possibly reducing efficacy. Barbiturates are inducers, so oral ruxolitinib exposure may fall.
What this interaction means in plain words
Ruxolitinib and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ruxolitinib belongs to Oncology; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP3A4 increases ruxolitinib metabolism.
What to do
Monitor for loss of response such as spleen size, counts or symptoms and consider an alternative sedative. Adjust ruxolitinib dose per clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Ruxolitinib with Secobarbital?
MediHelp rates the interaction as moderate. Ruxolitinib and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ruxolitinib is cleared mainly by CYP3A4, and strong inducers can lower its exposure, possibly reducing efficacy. Barbiturates are inducers, so oral ruxolitinib exposure may fall.
How serious is the interaction between Ruxolitinib and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of response such as spleen size, counts or symptoms and consider an alternative sedative. Adjust ruxolitinib dose per clinical response.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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