Drug interactions
Ruxolitinib + Valproic acid
Severity: Minor
Ruxolitinib and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valproate is not a recognized CYP3A4 inhibitor, so a clinically meaningful rise in ruxolitinib exposure is unlikely. Both drugs can contribute to cytopenias, notably thrombocytopenia. The interaction is mainly pharmacodynamic.
What this interaction means in plain words
Ruxolitinib and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ruxolitinib belongs to Oncology; Valproic acid belongs to Central Nervous System.
Why it happens
No established pharmacokinetic mechanism; additive myelosuppressive effects on platelets are possible.
What to do
Monitor the complete blood count, especially platelets, during combined therapy. Adjust ruxolitinib according to labeled platelet-based guidance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Ruxolitinib with Valproic acid?
MediHelp rates the interaction as minor. Ruxolitinib and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valproate is not a recognized CYP3A4 inhibitor, so a clinically meaningful rise in ruxolitinib exposure is unlikely. Both drugs can contribute to cytopenias, notably thrombocytopenia. The interaction is mainly pharmacodynamic.
How serious is the interaction between Ruxolitinib and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the complete blood count, especially platelets, during combined therapy. Adjust ruxolitinib according to labeled platelet-based guidance.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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