Drug interactions
Ruxolitinib + Verapamil
Severity: Moderate
Ruxolitinib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may increase ruxolitinib exposure, raising the risk of cytopenias such as thrombocytopenia and neutropenia.
What this interaction means in plain words
Ruxolitinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ruxolitinib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4, reducing ruxolitinib metabolism.
What to do
Monitor complete blood counts and adjust the ruxolitinib dose per labeling if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Ruxolitinib with Verapamil?
MediHelp rates the interaction as moderate. Ruxolitinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may increase ruxolitinib exposure, raising the risk of cytopenias such as thrombocytopenia and neutropenia.
How serious is the interaction between Ruxolitinib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and adjust the ruxolitinib dose per labeling if cytopenias develop.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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