Drug interactions
Safinamide + Talazoparib
Severity: Moderate
Safinamide and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide inhibits BCRP in vitro, and talazoparib is a BCRP substrate, so talazoparib exposure may rise. This could increase hematologic toxicity such as anemia, neutropenia and thrombocytopenia.
What this interaction means in plain words
Safinamide and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Safinamide belongs to Central Nervous System; Talazoparib belongs to Oncology.
Why it happens
Inhibition of BCRP-mediated efflux increases talazoparib absorption and exposure.
What to do
Monitor blood counts regularly and watch for adverse reactions. Reduce talazoparib dose or interrupt therapy per labeling if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Safinamide with Talazoparib?
MediHelp rates the interaction as moderate. Safinamide and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Safinamide inhibits BCRP in vitro, and talazoparib is a BCRP substrate, so talazoparib exposure may rise. This could increase hematologic toxicity such as anemia, neutropenia and thrombocytopenia.
How serious is the interaction between Safinamide and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly and watch for adverse reactions. Reduce talazoparib dose or interrupt therapy per labeling if toxicity develops.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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