Drug interactions
Salmeterol + Tucatinib
Severity: Moderate
Salmeterol and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a moderate CYP3A inhibitor and may raise salmeterol exposure. This can increase beta-agonist adverse effects such as tachycardia, tremor and QT prolongation.
What this interaction means in plain words
Salmeterol and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Salmeterol belongs to Respiratory; Tucatinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by tucatinib reduces salmeterol clearance.
What to do
Monitor heart rate, palpitations and potassium, and consider an alternative bronchodilator if symptoms emerge. Obtain an ECG in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Salmeterol with Tucatinib?
MediHelp rates the interaction as moderate. Salmeterol and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a moderate CYP3A inhibitor and may raise salmeterol exposure. This can increase beta-agonist adverse effects such as tachycardia, tremor and QT prolongation.
How serious is the interaction between Salmeterol and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, palpitations and potassium, and consider an alternative bronchodilator if symptoms emerge. Obtain an ECG in patients with cardiac risk factors.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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