Drug interactions
Salsalate + Silodosin
Severity: Minor
Salsalate and Silodosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is an NSAID-type salicylate that may reduce antihypertensive effects, but silodosin's urinary benefit is unlikely to be meaningfully affected.
What this interaction means in plain words
Salsalate and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical prostaglandin inhibition opposing vasodilation; not established for silodosin.
What to do
No routine action is needed. Monitor blood pressure if silodosin is also used with other antihypertensives.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Salsalate with Silodosin?
MediHelp rates the interaction as minor. Salsalate and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate is an NSAID-type salicylate that may reduce antihypertensive effects, but silodosin's urinary benefit is unlikely to be meaningfully affected.
How serious is the interaction between Salsalate and Silodosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Monitor blood pressure if silodosin is also used with other antihypertensives.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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