Drug interactions
Saquinavir + Silodosin
Severity: Contraindicated
Saquinavir and Silodosin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inhibitors such as ritonavir-boosted saquinavir can markedly raise silodosin concentrations, and strong CYP3A4 inhibitors are contraindicated with silodosin. Increased exposure raises the risk of severe hypotension and syncope. Saquinavir is also a P-gp inhibitor, which may add to the effect.
What this interaction means in plain words
Saquinavir and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces silodosin clearance.
What to do
Avoid the combination; choose an alternative alpha-blocker or antiretroviral regimen.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Saquinavir with Silodosin?
MediHelp rates the interaction as contraindicated. Saquinavir and Silodosin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Strong CYP3A4 inhibitors such as ritonavir-boosted saquinavir can markedly raise silodosin concentrations, and strong CYP3A4 inhibitors are contraindicated with silodosin. Increased exposure raises the risk of severe hypotension and syncope. Saquinavir is also a P-gp inhibitor, which may add to the effect.
How serious is the interaction between Saquinavir and Silodosin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose an alternative alpha-blocker or antiretroviral regimen.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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