Drug interactions
Saxagliptin + Tipranavir
Severity: Moderate
Saxagliptin and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, strongly inhibits CYP3A4 and may increase exposure to saxagliptin and its active metabolite. This can increase the risk of saxagliptin adverse effects.
What this interaction means in plain words
Saxagliptin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4/5-mediated saxagliptin metabolism by the ritonavir-boosted tipranavir regimen.
What to do
Limit saxagliptin to 2.5 mg once daily during coadministration. Monitor for adverse effects and glycemic control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Saxagliptin and Tipranavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Saxagliptin with Tipranavir?
MediHelp rates the interaction as moderate. Saxagliptin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, strongly inhibits CYP3A4 and may increase exposure to saxagliptin and its active metabolite. This can increase the risk of saxagliptin adverse effects.
How serious is the interaction between Saxagliptin and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg once daily during coadministration. Monitor for adverse effects and glycemic control.
What other medicines interact with Saxagliptin?
MediHelp also lists interactions of Saxagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Saxagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
