Drug interactions
Saxagliptin + Voriconazole
Severity: Moderate
Saxagliptin and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and raises saxagliptin and its active metabolite concentrations. This may increase dose-related adverse effects of saxagliptin.
What this interaction means in plain words
Saxagliptin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4/5-mediated saxagliptin metabolism by voriconazole.
What to do
Limit saxagliptin to 2.5 mg once daily while voriconazole is given. Monitor glycemic control and adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Saxagliptin with Voriconazole?
MediHelp rates the interaction as moderate. Saxagliptin and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4 and raises saxagliptin and its active metabolite concentrations. This may increase dose-related adverse effects of saxagliptin.
How serious is the interaction between Saxagliptin and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit saxagliptin to 2.5 mg once daily while voriconazole is given. Monitor glycemic control and adverse effects.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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