Drug interactions
Saxagliptin-metformin + Temsirolimus
Severity: Moderate
Saxagliptin-metformin and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus commonly causes hyperglycemia and may reduce the effect of antidiabetic drugs. Patients may need treatment intensification.
What this interaction means in plain words
Saxagliptin-metformin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Saxagliptin-metformin belongs to Endocrine; Temsirolimus belongs to Oncology.
Why it happens
Pharmacodynamic antagonism through mTOR inhibition causing insulin resistance.
What to do
Monitor glucose frequently during temsirolimus therapy. Adjust antidiabetic treatment as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Saxagliptin-metformin with Temsirolimus?
MediHelp rates the interaction as moderate. Saxagliptin-metformin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus commonly causes hyperglycemia and may reduce the effect of antidiabetic drugs. Patients may need treatment intensification.
How serious is the interaction between Saxagliptin-metformin and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently during temsirolimus therapy. Adjust antidiabetic treatment as required.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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