Drug interactions
Secobarbital + Sevoflurane
Severity: Moderate
Secobarbital and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates add to the anesthetic and respiratory depressant effects of sevoflurane. Deeper anesthesia, hypotension and prolonged recovery may result.
What this interaction means in plain words
Secobarbital and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Secobarbital belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression through enhancement of GABA-A receptor activity.
What to do
Inform the anesthesia team of recent barbiturate use and titrate the sevoflurane concentration to depth monitoring. Monitor ventilation and blood pressure during and after anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Secobarbital with Sevoflurane?
MediHelp rates the interaction as moderate. Secobarbital and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates add to the anesthetic and respiratory depressant effects of sevoflurane. Deeper anesthesia, hypotension and prolonged recovery may result.
How serious is the interaction between Secobarbital and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of recent barbiturate use and titrate the sevoflurane concentration to depth monitoring. Monitor ventilation and blood pressure during and after anesthesia.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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