Drug interactions
Secobarbital + Sotalol
Severity: Minor
Secobarbital and Sotalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and can lower levels of beta-blockers that are metabolized by the liver. Sotalol is eliminated almost entirely unchanged by the kidneys, so any reduction in its effect is expected to be small.
What this interaction means in plain words
Secobarbital and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Secobarbital belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Barbiturate induction of hepatic CYP enzymes, which has little relevance to sotalol because it undergoes negligible hepatic metabolism.
What to do
No routine dose change is needed; monitor heart rate and blood pressure or arrhythmia control if a barbiturate is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Secobarbital with Sotalol?
MediHelp rates the interaction as minor. Secobarbital and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes and can lower levels of beta-blockers that are metabolized by the liver. Sotalol is eliminated almost entirely unchanged by the kidneys, so any reduction in its effect is expected to be small.
How serious is the interaction between Secobarbital and Sotalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor heart rate and blood pressure or arrhythmia control if a barbiturate is started or stopped.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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