Drug interactions
Secobarbital + Stiripentol
Severity: Major
Secobarbital and Stiripentol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may induce CYP3A4 and other enzymes involved in stiripentol clearance, lowering its levels. This could reduce seizure control in patients with Dravet syndrome. Stiripentol also inhibits some enzymes that clear barbiturates, so the net effect is complicated.
What this interaction means in plain words
Secobarbital and Stiripentol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Secobarbital belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Enzyme induction by the barbiturate raises stiripentol clearance, while stiripentol inhibition may increase barbiturate levels.
What to do
Avoid the combination where possible. If both are necessary, monitor seizure control and sedation, and consider adjusting the stiripentol dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Secobarbital with Stiripentol?
MediHelp rates the interaction as major. Secobarbital and Stiripentol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital may induce CYP3A4 and other enzymes involved in stiripentol clearance, lowering its levels. This could reduce seizure control in patients with Dravet syndrome. Stiripentol also inhibits some enzymes that clear barbiturates, so the net effect is complicated.
How serious is the interaction between Secobarbital and Stiripentol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are necessary, monitor seizure control and sedation, and consider adjusting the stiripentol dose.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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