Drug interactions
Secobarbital + Tramadol
Severity: Major
Secobarbital and Tramadol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital induces CYP3A4 and may lower tramadol levels, reducing analgesia. At the same time barbiturates and opioids additively depress CNS and respiration, and tramadol lowers seizure threshold.
What this interaction means in plain words
Secobarbital and Tramadol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Secobarbital belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Enzyme induction by secobarbital increases tramadol clearance, combined with additive CNS and respiratory depression.
What to do
Avoid combining where possible, and use the lowest effective doses if needed. Monitor sedation, respiratory rate and pain control.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Secobarbital with Tramadol?
MediHelp rates the interaction as major. Secobarbital and Tramadol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Secobarbital induces CYP3A4 and may lower tramadol levels, reducing analgesia. At the same time barbiturates and opioids additively depress CNS and respiration, and tramadol lowers seizure threshold.
How serious is the interaction between Secobarbital and Tramadol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, and use the lowest effective doses if needed. Monitor sedation, respiratory rate and pain control.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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