Drug interactions
Secobarbital + Trazodone
Severity: Moderate
Secobarbital and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination increases sedation and impairment of alertness. Secobarbital may also reduce trazodone concentrations through enzyme induction, potentially weakening antidepressant effect.
What this interaction means in plain words
Secobarbital and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Secobarbital belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression plus barbiturate induction of CYP3A4-mediated trazodone metabolism.
What to do
Monitor for oversedation and for reduced antidepressant response. Adjust the trazodone dose to clinical effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Secobarbital with Trazodone?
MediHelp rates the interaction as moderate. Secobarbital and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination increases sedation and impairment of alertness. Secobarbital may also reduce trazodone concentrations through enzyme induction, potentially weakening antidepressant effect.
How serious is the interaction between Secobarbital and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and for reduced antidepressant response. Adjust the trazodone dose to clinical effect.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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