Drug interactions
Secukinumab + Trastuzumab
Severity: Moderate
Secukinumab and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secukinumab increases susceptibility to infections through IL-17A inhibition, and trastuzumab is associated with neutropenia particularly alongside chemotherapy. Combined use may raise infection risk, though no specific interaction is well characterized.
What this interaction means in plain words
Secukinumab and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Secukinumab belongs to Miscellaneous; Trastuzumab belongs to Oncology.
Why it happens
Additive pharmacodynamic effects on infection risk; no direct pharmacokinetic interaction.
What to do
Monitor for signs of infection and check blood counts during therapy. Consider holding secukinumab if serious infection occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Secukinumab with Trastuzumab?
MediHelp rates the interaction as moderate. Secukinumab and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secukinumab increases susceptibility to infections through IL-17A inhibition, and trastuzumab is associated with neutropenia particularly alongside chemotherapy. Combined use may raise infection risk, though no specific interaction is well characterized.
How serious is the interaction between Secukinumab and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts during therapy. Consider holding secukinumab if serious infection occurs.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
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