Drug interactions
Selegiline + Teriflunomide
Severity: Minor
Selegiline and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide inhibits CYP2C8, but selegiline is not mainly cleared by CYP2C8, so a clinically important rise in selegiline levels is unlikely. No meaningful interaction is established.
What this interaction means in plain words
Selegiline and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Selegiline belongs to Central Nervous System; Teriflunomide belongs to Central Nervous System.
Why it happens
Weak CYP2C8 inhibition by teriflunomide with minor relevance to selegiline metabolism.
What to do
No routine adjustment is needed. Watch for increased selegiline adverse effects if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Teriflunomide
Frequently asked questions
Can I take Selegiline with Teriflunomide?
MediHelp rates the interaction as minor. Selegiline and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide inhibits CYP2C8, but selegiline is not mainly cleared by CYP2C8, so a clinically important rise in selegiline levels is unlikely. No meaningful interaction is established.
How serious is the interaction between Selegiline and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for increased selegiline adverse effects if symptoms arise.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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