Drug interactions
Selinexor + Tapentadol
Severity: Moderate
Selinexor and Tapentadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and fatigue, and tapentadol also causes dizziness and sedation. Together they may increase neurological toxicity and the risk of falls or impaired thinking.
What this interaction means in plain words
Selinexor and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Selinexor belongs to Oncology; Tapentadol belongs to Musculoskeletal.
Why it happens
Additive CNS adverse effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and sedation, and counsel patients on fall risk and driving. Reduce the opioid dose or adjust selinexor if neurological symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Selinexor with Tapentadol?
MediHelp rates the interaction as moderate. Selinexor and Tapentadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and fatigue, and tapentadol also causes dizziness and sedation. Together they may increase neurological toxicity and the risk of falls or impaired thinking.
How serious is the interaction between Selinexor and Tapentadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation, and counsel patients on fall risk and driving. Reduce the opioid dose or adjust selinexor if neurological symptoms occur.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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