Drug interactions
Sertraline + Sotalol
Severity: Moderate
Sertraline and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline has a low potential for QT prolongation, but sotalol is a strong QT-prolonging drug, so the combination may add to the risk of torsades de pointes in susceptible patients. Risk is higher with bradycardia, electrolyte disturbance or renal impairment.
What this interaction means in plain words
Sertraline and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Additive, mostly sotalol-driven, delay of cardiac repolarization; sertraline has a weak effect on QT.
What to do
Check baseline ECG and electrolytes, and monitor QTc when starting or increasing either drug. Correct potassium and magnesium deficits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Sertraline with Sotalol?
MediHelp rates the interaction as moderate. Sertraline and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline has a low potential for QT prolongation, but sotalol is a strong QT-prolonging drug, so the combination may add to the risk of torsades de pointes in susceptible patients. Risk is higher with bradycardia, electrolyte disturbance or renal impairment.
How serious is the interaction between Sertraline and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes, and monitor QTc when starting or increasing either drug. Correct potassium and magnesium deficits.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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