Drug interactions
Sertraline + Stiripentol
Severity: Moderate
Sertraline and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits several CYP enzymes including CYP2C19 and may raise sertraline concentrations. Both drugs can cause sedation, so somnolence and other adverse effects may increase.
What this interaction means in plain words
Sertraline and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP2C19 and other enzymes involved in sertraline metabolism, with additive CNS depression.
What to do
Start sertraline at a low dose and titrate carefully. Monitor for sedation, serotonergic effects and seizure control, and reduce the sertraline dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Sertraline with Stiripentol?
MediHelp rates the interaction as moderate. Sertraline and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits several CYP enzymes including CYP2C19 and may raise sertraline concentrations. Both drugs can cause sedation, so somnolence and other adverse effects may increase.
How serious is the interaction between Sertraline and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start sertraline at a low dose and titrate carefully. Monitor for sedation, serotonergic effects and seizure control, and reduce the sertraline dose if adverse effects occur.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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