Drug interactions
Sertraline + Tedizolid
Severity: Major
Sertraline and Tedizolid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline is an SSRI, and tedizolid is a weak reversible MAO inhibitor. The combination carries a theoretical risk of serotonin syndrome, which can be serious. Clinical data are limited and the observed risk with tedizolid appears low.
What this interaction means in plain words
Sertraline and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Sertraline belongs to Central Nervous System; Tedizolid belongs to Anti Bacterial.
Why it happens
Additive serotonergic effects from SSRI reuptake blockade and weak MAO inhibition by tedizolid.
What to do
Avoid if an alternative antibiotic is suitable. If co-prescribed, monitor for features of serotonin syndrome and stop one agent if they appear.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Sertraline with Tedizolid?
MediHelp rates the interaction as major. Sertraline and Tedizolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sertraline is an SSRI, and tedizolid is a weak reversible MAO inhibitor. The combination carries a theoretical risk of serotonin syndrome, which can be serious. Clinical data are limited and the observed risk with tedizolid appears low.
How serious is the interaction between Sertraline and Tedizolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative antibiotic is suitable. If co-prescribed, monitor for features of serotonin syndrome and stop one agent if they appear.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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