Drug interactions
Sertraline + Telotristat etiprate
Severity: Minor
Sertraline and Telotristat etiprate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat may reduce sertraline exposure through effects on CYP2B6-mediated metabolism, which could lessen antidepressant effect. The magnitude is uncertain, since sertraline is cleared by several enzymes.
What this interaction means in plain words
Sertraline and Telotristat etiprate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Sertraline belongs to Central Nervous System; Telotristat etiprate belongs to Gastrointestinal Tract.
Why it happens
Possible CYP2B6 induction increasing sertraline metabolism.
What to do
Monitor mood and symptom control, and titrate sertraline if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Telotristat etiprate
- Bupropion + Telotristat etiprate Moderate
- Capecitabine + Telotristat etiprate Moderate
- Everolimus + Telotristat etiprate Moderate
- Flutamide + Telotristat etiprate Moderate
- Irinotecan + Telotristat etiprate Moderate
- Midazolam + Telotristat etiprate Moderate
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Sertraline with Telotristat etiprate?
MediHelp rates the interaction as minor. Sertraline and Telotristat etiprate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telotristat may reduce sertraline exposure through effects on CYP2B6-mediated metabolism, which could lessen antidepressant effect. The magnitude is uncertain, since sertraline is cleared by several enzymes.
How serious is the interaction between Sertraline and Telotristat etiprate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mood and symptom control, and titrate sertraline if response is inadequate.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Capecitabine, Everolimus. The full list is on the Telotristat etiprate page.
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