Drug interactions
Sertraline + Triclabendazole
Severity: Moderate
Sertraline and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole may inhibit CYP2C19 and raise sertraline levels, and both drugs can prolong the QT interval. The combination may therefore increase arrhythmia risk and sertraline adverse effects.
What this interaction means in plain words
Sertraline and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
CYP2C19 inhibition raising sertraline exposure plus additive QT prolongation.
What to do
Consider an ECG and correct electrolyte abnormalities in patients with QT risk factors. Monitor for sertraline adverse effects during the short triclabendazole course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Triclabendazole
Frequently asked questions
Can I take Sertraline with Triclabendazole?
MediHelp rates the interaction as moderate. Sertraline and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclabendazole may inhibit CYP2C19 and raise sertraline levels, and both drugs can prolong the QT interval. The combination may therefore increase arrhythmia risk and sertraline adverse effects.
How serious is the interaction between Sertraline and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG and correct electrolyte abnormalities in patients with QT risk factors. Monitor for sertraline adverse effects during the short triclabendazole course.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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