Drug interactions
Sertraline + Valbenazine
Severity: Moderate
Sertraline and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine can cause modest QT prolongation, particularly when exposure is raised, and sertraline has a small QT effect. Combined use may add to arrhythmia risk in susceptible patients.
What this interaction means in plain words
Sertraline and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sertraline belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation through pharmacodynamic effects.
What to do
Consider an ECG at baseline and after dose changes in patients with cardiac risk factors or electrolyte abnormalities. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Sertraline with Valbenazine?
MediHelp rates the interaction as moderate. Sertraline and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine can cause modest QT prolongation, particularly when exposure is raised, and sertraline has a small QT effect. Combined use may add to arrhythmia risk in susceptible patients.
How serious is the interaction between Sertraline and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG at baseline and after dose changes in patients with cardiac risk factors or electrolyte abnormalities. Correct potassium and magnesium abnormalities.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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