Drug interactions
Sevoflurane + Tranylcypromine
Severity: Moderate
Sevoflurane and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patients on MAO inhibitors may show exaggerated or unstable hemodynamic responses during general anesthesia. Volatile anesthetics can add to the hypotension seen with tranylcypromine.
What this interaction means in plain words
Sevoflurane and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on autonomic and cardiovascular regulation; the mechanism is not fully defined.
What to do
Inform the anesthesia team about MAOI use and monitor blood pressure and heart rate continuously. Avoid indirect-acting sympathomimetics and meperidine, and have direct-acting vasopressors available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Sevoflurane with Tranylcypromine?
MediHelp rates the interaction as moderate. Sevoflurane and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Patients on MAO inhibitors may show exaggerated or unstable hemodynamic responses during general anesthesia. Volatile anesthetics can add to the hypotension seen with tranylcypromine.
How serious is the interaction between Sevoflurane and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team about MAOI use and monitor blood pressure and heart rate continuously. Avoid indirect-acting sympathomimetics and meperidine, and have direct-acting vasopressors available.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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