Drug interactions
Sevoflurane + Vardenafil
Severity: Moderate
Sevoflurane and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval and vardenafil has a modest QT effect. Combined use may add to arrhythmia risk, and both can lower blood pressure.
What this interaction means in plain words
Sevoflurane and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Vardenafil belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation with possible additive vasodilation.
What to do
Tell the anesthesia team about recent vardenafil use and monitor ECG and blood pressure. Correct electrolyte abnormalities before surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Sevoflurane with Vardenafil?
MediHelp rates the interaction as moderate. Sevoflurane and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval and vardenafil has a modest QT effect. Combined use may add to arrhythmia risk, and both can lower blood pressure.
How serious is the interaction between Sevoflurane and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about recent vardenafil use and monitor ECG and blood pressure. Correct electrolyte abnormalities before surgery.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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