Drug interactions
Sevoflurane + Voclosporin
Severity: Moderate
Sevoflurane and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can prolong the QT interval at supratherapeutic exposure, and sevoflurane also affects cardiac repolarization. Combined use may modestly increase arrhythmia risk, particularly with electrolyte abnormalities.
What this interaction means in plain words
Sevoflurane and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Voclosporin belongs to Miscellaneous.
Why it happens
Additive QT interval prolongation.
What to do
Check electrolytes and ECG before anesthesia in patients with cardiac risk factors. Monitor the ECG during the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Sevoflurane with Voclosporin?
MediHelp rates the interaction as moderate. Sevoflurane and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin can prolong the QT interval at supratherapeutic exposure, and sevoflurane also affects cardiac repolarization. Combined use may modestly increase arrhythmia risk, particularly with electrolyte abnormalities.
How serious is the interaction between Sevoflurane and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check electrolytes and ECG before anesthesia in patients with cardiac risk factors. Monitor the ECG during the procedure.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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