Drug interactions
Sevoflurane + Ziprasidone
Severity: Moderate
Sevoflurane and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval, and ziprasidone has the same effect. Under anesthesia this increases the risk of torsades de pointes, especially with electrolyte disturbance.
What this interaction means in plain words
Sevoflurane and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sevoflurane belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization (QTc).
What to do
Review the preoperative ECG, correct potassium and magnesium, and monitor the ECG continuously. Avoid adding other QT-prolonging perioperative drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Sevoflurane with Ziprasidone?
MediHelp rates the interaction as moderate. Sevoflurane and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval, and ziprasidone has the same effect. Under anesthesia this increases the risk of torsades de pointes, especially with electrolyte disturbance.
How serious is the interaction between Sevoflurane and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the preoperative ECG, correct potassium and magnesium, and monitor the ECG continuously. Avoid adding other QT-prolonging perioperative drugs where possible.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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