Drug interactions
Sildenafil + Silodosin
Severity: Moderate
Sildenafil and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Silodosin is a selective alpha-1A blocker, and its combination with sildenafil can cause additive orthostatic hypotension, dizziness or syncope. Its uroselectivity makes this less pronounced than with nonselective alpha-blockers.
What this interaction means in plain words
Sildenafil and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Sildenafil belongs to Genitourinary; Silodosin belongs to Genitourinary.
Why it happens
Additive vasodilatory effects of PDE5 inhibition and alpha-1 adrenergic blockade.
What to do
Start sildenafil at 25 mg once the patient is stable on silodosin. Counsel on orthostatic symptoms and monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Sildenafil with Silodosin?
MediHelp rates the interaction as moderate. Sildenafil and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Silodosin is a selective alpha-1A blocker, and its combination with sildenafil can cause additive orthostatic hypotension, dizziness or syncope. Its uroselectivity makes this less pronounced than with nonselective alpha-blockers.
How serious is the interaction between Sildenafil and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start sildenafil at 25 mg once the patient is stable on silodosin. Counsel on orthostatic symptoms and monitor blood pressure.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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