Drug interactions
Silodosin + Yohimbe
Severity: Moderate
Silodosin and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbe contains yohimbine, an alpha-2 antagonist that raises sympathetic tone and blood pressure, which opposes alpha-1 blockade. Effects are unpredictable, with possible reduced silodosin efficacy or blood pressure swings and palpitations.
What this interaction means in plain words
Silodosin and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism between yohimbine's noradrenergic stimulation and silodosin's alpha-1 blockade.
What to do
Advise avoiding yohimbe supplements while on silodosin and monitor blood pressure and heart rate if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Silodosin with Yohimbe?
MediHelp rates the interaction as moderate. Silodosin and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbe contains yohimbine, an alpha-2 antagonist that raises sympathetic tone and blood pressure, which opposes alpha-1 blockade. Effects are unpredictable, with possible reduced silodosin efficacy or blood pressure swings and palpitations.
How serious is the interaction between Silodosin and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding yohimbe supplements while on silodosin and monitor blood pressure and heart rate if used.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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