Drug interactions
Siltuximab + Warfarin
Severity: Moderate
Siltuximab and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Interleukin-6 suppresses CYP450 enzymes during inflammation, so blocking IL-6 with siltuximab may restore enzyme activity. Warfarin clearance may rise, reducing INR and anticoagulant effect, and the change can persist for weeks after stopping.
What this interaction means in plain words
Siltuximab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Siltuximab belongs to Miscellaneous; Warfarin belongs to Cardiovascular.
Why it happens
IL-6 blockade normalizes suppressed CYP450 expression, increasing warfarin metabolism.
What to do
Monitor INR more frequently when starting or stopping siltuximab and adjust the warfarin dose for several weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siltuximab
- Baricitinib + Siltuximab Major
- Atorvastatin + Siltuximab Moderate
- Carbamazepine + Siltuximab Moderate
- Cyclosporin + Siltuximab Moderate
- Ethinyl estradiol-drospirenone + Siltuximab Moderate
- Ethinyl estradiol-levonorgestrel + Siltuximab Moderate
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Siltuximab with Warfarin?
MediHelp rates the interaction as moderate. Siltuximab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Interleukin-6 suppresses CYP450 enzymes during inflammation, so blocking IL-6 with siltuximab may restore enzyme activity. Warfarin clearance may rise, reducing INR and anticoagulant effect, and the change can persist for weeks after stopping.
How serious is the interaction between Siltuximab and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently when starting or stopping siltuximab and adjust the warfarin dose for several weeks.
What other medicines interact with Siltuximab?
MediHelp also lists interactions of Siltuximab with, for example, Baricitinib, Atorvastatin, Carbamazepine. The full list is on the Siltuximab page.
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