Drug interactions
Simvastatin + Stiripentol
Severity: Moderate
Simvastatin and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol affects CYP3A4 and P-glycoprotein and may alter simvastatin exposure unpredictably. Raised levels increase myopathy risk, while induction may reduce efficacy.
What this interaction means in plain words
Simvastatin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Simvastatin belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol both inhibits and induces CYP3A4 and inhibits P-glycoprotein.
What to do
Monitor for muscle symptoms and lipid response, and adjust the simvastatin dose accordingly. Consider a statin less dependent on CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Simvastatin with Stiripentol?
MediHelp rates the interaction as moderate. Simvastatin and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol affects CYP3A4 and P-glycoprotein and may alter simvastatin exposure unpredictably. Raised levels increase myopathy risk, while induction may reduce efficacy.
How serious is the interaction between Simvastatin and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and lipid response, and adjust the simvastatin dose accordingly. Consider a statin less dependent on CYP3A4.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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