Drug interactions
Simvastatin + Telotristat etiprate
Severity: Moderate
Simvastatin and Telotristat etiprate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat can lower simvastatin exposure by inducing CYP3A4, which may reduce lipid-lowering efficacy.
What this interaction means in plain words
Simvastatin and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Simvastatin belongs to Cardiovascular; Telotristat etiprate belongs to Gastrointestinal Tract.
Why it happens
CYP3A4 induction increases simvastatin first-pass and systemic metabolism.
What to do
Check lipid profile after starting telotristat and increase the statin dose or switch to a statin not dependent on CYP3A4 if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telotristat etiprate
- Bupropion + Telotristat etiprate Moderate
- Capecitabine + Telotristat etiprate Moderate
- Everolimus + Telotristat etiprate Moderate
- Flutamide + Telotristat etiprate Moderate
- Irinotecan + Telotristat etiprate Moderate
- Midazolam + Telotristat etiprate Moderate
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Simvastatin with Telotristat etiprate?
MediHelp rates the interaction as moderate. Simvastatin and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat can lower simvastatin exposure by inducing CYP3A4, which may reduce lipid-lowering efficacy.
How serious is the interaction between Simvastatin and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check lipid profile after starting telotristat and increase the statin dose or switch to a statin not dependent on CYP3A4 if needed.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Capecitabine, Everolimus. The full list is on the Telotristat etiprate page.
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